About Gene List

PF3D7_1224400

Genome location: Pf3D7_12_v3:993,227..996,884(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
Component GO:0005634 nucleus
Component GO:0032040 small-subunit processome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.86 0.61
Trophozoite expressed 0.38 0.79
Schizont not expressed 0.12 0.93
Gametocyte not expressed 0.38 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1224400

Resistome Missense Mutations: D197N

Resistome Compounds with Missense Mutations: GNF-Pf-5611

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.218 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5H3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532397

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 19 12 27
disruptive 8 42 39 84
missense 8 41 38 71

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 38 22 34
disruptive 24 123 69 172
missense 18 102 56 100

PlasmoDB Total SNPs: 190

Non-coding: 142 | Synonymous: 32 | Nonsynonymous: 15 | Stop Codon: 1

Protein Information

Protein Length: 595 | Molecular Weight (kDa): 71.245

UniProt ID(s): Q8I5H3

PDB ID(s): None

Isoelectric Point: 6.65

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036322 WD40-repeat-containing domain superfamily
PFam N/A N/A
Superfamily SSF50978 WD40-repeat-containing domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108