Product Description: histone chaperone ASF1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0042393 | histone binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006335 | DNA replication-dependent chromatin assembly |
| Process | GO:0006336 | DNA replication-independent chromatin assembly |
| Process | GO:0031497 | chromatin assembly |
| Process | GO:0016458 | gene silencing |
| Process | GO:0043486 | histone exchange |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.34 | 0.79 |
| Schizont | expressed | 0.28 | 0.81 |
| Gametocyte | expressed | 0.38 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1224500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.411 | MFS: -2.479 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5H2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101293
Most Similar Human Ortholog: K7EIL9
TM-align score: 0.88 | RMSD: 2.00
Seq Identity: 0.35 | Length: 80 / 273
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105011 | anti-silencing function 1B histone chaperone |
| ENSG00000111875 | anti-silencing function 1A histone chaperone |
| ENSG00000288210 | anti-silencing function 1B histone chaperone |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 141
Non-coding: 137 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 273 | Molecular Weight (kDa): 31.547
UniProt ID(s): Q8I5H2
PDB ID(s): 6A6Y
Isoelectric Point: 4.1
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006818 | Histone chaperone ASF1-like |
| InterPro | IPR017282 | Histone deposition protein Asf1 |
| InterPro | IPR036747 | Histone chaperone ASF1-like superfamily |
| PFam | PF04729 | Histone chaperone ASF1-like |
| Superfamily | SSF101546 | Histone chaperone ASF1-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 33501928 | Structural insights into histone chaperone Asf1 and its characterization fromPlasmodium falciparum. | Srivastava DK, Gunjan S, ..., Roy S | 10.1042/BCJ20200891 |
| 38407959 | A fluorescent assay for cryptic transcription in Saccharomyces cerevisiae revealsnovel insights into factors that stabilize chromatin structure on newlyreplicated DNA | Gao E, Brown JAR, Jung S, Howe LJ | 10.1093/genetics/iyae016 |
| 36914923 | The patterns and participants of parental histone recycling during DNAreplication in Saccharomyces cerevisiae | Shan Z, Zhang Y, ..., Zhu B | 10.1007/s11427-022-2267-6 |