PF3D7_1224700

Genome location: Pf3D7_12_v3:1,002,756..1,008,521(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.99	0.57
Trophozoite	not expressed	0.59	0.67
Schizont	not expressed	0.80	0.56
Gametocyte	not expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1224700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.952 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5H0

"Best" AlphaFill ligand hit: BEZ (benzoic acid, Local RMSD=1.53) with 2Q9R (Global RMSD=53.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532727

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	49	40	49
disruptive	45	166	105	234
missense	28	136	89	205

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	103	42	70
disruptive	71	354	181	346
missense	46	274	155	256

PlasmoDB Total SNPs: 216

Non-coding: 79 | Synonymous: 83 | Nonsynonymous: 53 | Stop Codon: 1

Protein Information

Protein Length: 1461 | Molecular Weight (kDa): 171.513

UniProt ID(s): Q8I5H0

PDB ID(s): None

Isoelectric Point: 5.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A