PF3D7_1224800

Genome location: Pf3D7_12_v3:1,008,635..1,010,588(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	possibly expressed	0.31	0.81
Schizont	possibly expressed	0.29	0.81
Gametocyte	expressed	0.33	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1224800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.94 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5G9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139467

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	8	21
disruptive	5	26	14	26
missense	5	25	13	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	25	16	19
disruptive	14	60	22	67
missense	11	44	20	50

PlasmoDB Total SNPs: 108

Non-coding: 86 | Synonymous: 11 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 320 | Molecular Weight (kDa): 37.373

UniProt ID(s): Q8I5G9

PDB ID(s): None

Isoelectric Point: 10.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A