Genome location: Pf3D7_12_v3:1,010,680..1,011,767(-)
Genome classification: Core
Product Description: splicing factor 3B subunit 6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005689 | U12-type spliceosomal complex |
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0005684 | U2-type spliceosomal complex |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0071011 | precatalytic spliceosome |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.57 | 0.73 |
| Trophozoite | expressed | 0.46 | 0.73 |
| Schizont | expressed | 0.27 | 0.82 |
| Gametocyte | expressed | 0.80 | 0.56 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1224900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.985 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5G8
"Best" AlphaFill ligand hit: 15P (peg 1500, Local RMSD=0.11) with 6F4J (Global RMSD=4.24)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102600
Most Similar Human Ortholog: Q9Y3B4
TM-align score: 0.87 | RMSD: 1.85
Seq Identity: 0.67 | Length: 100 / 106
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115128 | splicing factor 3b subunit 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 59
Non-coding: 52 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 106 | Molecular Weight (kDa): 12.263
UniProt ID(s): Q8I5G8
PDB ID(s): None
Isoelectric Point: 10.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR034150 | SF3B6, RNA recognition motif |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35028595 | Rewards of divergence in sequences, 3-D structures and dynamics of yeast andhuman spliceosome SF3b complexes | Yazhini A, Sandhya S, Srinivasan N | 10.1016/j.crstbi.2021.05.003 |