About Gene List

PF3D7_1225000

Genome location: Pf3D7_12_v3:1,012,310..1,017,848(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite not expressed 0.28 0.84
Schizont possibly expressed 0.03 0.98
Gametocyte not expressed 0.51 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1225000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -3.163 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1439900)

  • Relative Growth Rate: 0.03 ± 0.04
  • Confidence: 7.93

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5G7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532542

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 66 29 68
disruptive 29 147 96 234
missense 23 131 89 207

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 124 56 108
disruptive 76 349 207 402
missense 43 286 170 291

PlasmoDB Total SNPs: 152

Non-coding: 44 | Synonymous: 63 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 1728 | Molecular Weight (kDa): 209.565

UniProt ID(s): Q8I5G7

PDB ID(s): None

Isoelectric Point: 10.26

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104