About Gene List

PF3D7_1225200

Genome location: Pf3D7_12_v3:1,024,322..1,028,668(-)

Genome classification: Core

Function and Localization

Product Description: DNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.73 0.66
Trophozoite expressed 0.73 0.59
Schizont expressed 0.29 0.82
Gametocyte possibly expressed 0.57 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1225200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.017 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5G5

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.68) with 3MMR (Global RMSD=20.72)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533555

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 51 30 54
disruptive 50 168 78 210
missense 23 118 59 154

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 28 92 55 66
disruptive 97 362 173 410
missense 39 242 130 258

PlasmoDB Total SNPs: 211

Non-coding: 35 | Synonymous: 113 | Nonsynonymous: 62 | Stop Codon: 1

Protein Information

Protein Length: 1187 | Molecular Weight (kDa): 138.143

UniProt ID(s): Q8I5G5

PDB ID(s): None

Isoelectric Point: 6.29

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001005 SANT/Myb domain
InterPro IPR009057 Homeobox-like domain superfamily
PFam PF00249 SANT/Myb domain
Superfamily SSF46689 Homeobox-like domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108