PF3D7_1225300

Genome location: Pf3D7_12_v3:1,029,020..1,031,737(+)

Genome classification: Core

Function and Localization

Product Description: rRNA-processing protein FCF1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome
Function	GO:0070181	small ribosomal subunit rRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.50	0.76
Trophozoite	expressed	0.36	0.79
Schizont	not expressed	0.11	0.93
Gametocyte	expressed	0.34	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1225300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.827 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5G4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102991

Most Similar Human Ortholog: E5RGP0

TM-align score: 0.79 | RMSD: 3.18

Seq Identity: 0.21 | Length: 152 / 346

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000147679	UTP23 small subunit processome component

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	14	7	24
disruptive	7	46	18	53
missense	7	45	16	48

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	29	16	16
disruptive	20	100	47	94
missense	14	82	40	54

PlasmoDB Total SNPs: 213

Non-coding: 176 | Synonymous: 22 | Nonsynonymous: 14 | Stop Codon: 1

Protein Information

Protein Length: 346 | Molecular Weight (kDa): 40.74

UniProt ID(s): Q8I5G4

PDB ID(s): None

Isoelectric Point: 9.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006984	rRNA-processing protein Fcf1/Utp23
PFam	PF04900	rRNA-processing protein Fcf1/Utp23
Superfamily	N/A	N/A