About Gene List

PF3D7_1225400

Genome location: Pf3D7_12_v3:1,031,628..1,032,790(-)

Genome classification: Core

Function and Localization

Product Description: rRNA-processing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.34 0.83
Trophozoite possibly expressed 0.20 0.89
Schizont possibly expressed 0.05 0.97
Gametocyte not expressed 0.45 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1225400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -2.742 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5G3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533469

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 7 7 11
disruptive 5 28 19 42
missense 3 23 15 37

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 15 9 20
disruptive 16 68 41 73
missense 6 46 35 47

PlasmoDB Total SNPs: 46

Non-coding: 33 | Synonymous: 5 | Nonsynonymous: 7 | Stop Codon: 1

Protein Information

Protein Length: 246 | Molecular Weight (kDa): 29.286

UniProt ID(s): Q8I5G3

PDB ID(s): None

Isoelectric Point: 10.38

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013730 Fyv7/TAP26
PFam PF08524 Fyv7/TAP26
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g