PF3D7_1226000

Genome location: Pf3D7_12_v3:1,053,194..1,056,616(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.11	0.94
Trophozoite	expressed	0.20	0.88
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.33	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1226000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.559 | MFS: -3.059 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5F7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_153771

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	29	29	53
disruptive	14	74	41	124
missense	12	72	40	119

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	76	27	67
disruptive	21	168	93	170
missense	16	141	86	143

PlasmoDB Total SNPs: 136

Non-coding: 71 | Synonymous: 39 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 908 | Molecular Weight (kDa): 108.486

UniProt ID(s): Q8I5F7

PDB ID(s): None

Isoelectric Point: 9.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A