PF3D7_1226400

Genome location: Pf3D7_12_v3:1,067,269..1,071,520(-)

Genome classification: Core

Function and Localization

Product Description: regulator of MON1-CCZ1 complex, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0035658	Mon1-Ccz1 complex
Component	GO:0031902	late endosome membrane
Process	GO:0010506	regulation of autophagy

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.13	0.93
Trophozoite	expressed	0.53	0.69
Schizont	possibly expressed	0.24	0.84
Gametocyte	expressed	0.37	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1226400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.138 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5F3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136524

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	44	29	35
disruptive	17	65	30	91
missense	16	62	29	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	80	37	46
disruptive	35	135	91	154
missense	26	109	80	120

PlasmoDB Total SNPs: 305

Non-coding: 232 | Synonymous: 47 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 856 | Molecular Weight (kDa): 101.997

UniProt ID(s): Q8I5F3

PDB ID(s): None

Isoelectric Point: 7.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009755	Regulator of MON1-CCZ1 complex, C-terminal
InterPro	IPR040371	Regulator of MON1-CCZ1 complex
PFam	PF07035	Regulator of MON1-CCZ1 complex, C-terminal
Superfamily	N/A	N/A