PF3D7_1226500

Genome location: Pf3D7_12_v3:1,072,459..1,076,976(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat and RAP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	possibly expressed	0.24	0.86
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.34	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1226500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -2.935 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5F2

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=8.92) with 4IFC (Global RMSD=15.39)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130931

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	60	34	99
disruptive	68	182	92	192
missense	44	133	78	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	123	51	100
disruptive	127	325	152	306
missense	67	232	124	226

PlasmoDB Total SNPs: 135

Non-coding: 0 | Synonymous: 63 | Nonsynonymous: 72 | Stop Codon: 0

Protein Information

Protein Length: 1505 | Molecular Weight (kDa): 179.852

UniProt ID(s): Q8I5F2

PDB ID(s): None

Isoelectric Point: 9.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A