Genome location: Pf3D7_12_v3:1,079,971..1,083,396(+)
Genome classification: Core
Product Description: U3 small nucleolar RNA-interacting protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031428 | box C/D RNP complex |
| Component | GO:0005730 | nucleolus |
| Component | GO:0032040 | small-subunit processome |
| Function | GO:0034511 | U3 snoRNA binding |
| Function | GO:0030515 | snoRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.32 | 0.84 |
| Trophozoite | expressed | 0.36 | 0.79 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1226700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.894 | #Insertions: 2
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1441500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5F1
"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.35) with 4GM3 (Global RMSD=2.92)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102033
Most Similar Human Ortholog: O43818
TM-align score: 0.70 | RMSD: 2.88
Seq Identity: 0.21 | Length: 361 / 636
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000114767 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 15 | 40 |
| disruptive | 10 | 51 | 38 | 120 |
| missense | 10 | 48 | 38 | 109 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 53 | 24 | 47 |
| disruptive | 22 | 153 | 86 | 178 |
| missense | 16 | 131 | 75 | 120 |
PlasmoDB Total SNPs: 118
Non-coding: 90 | Synonymous: 19 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 636 | Molecular Weight (kDa): 73.863
UniProt ID(s): Q8I5F1
PDB ID(s): None
Isoelectric Point: 6.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR020472 | G-protein beta WD-40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| InterPro | IPR039241 | Ribosomal RNA-processing protein Rrp9-like |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 11105764 | Yeast Rrp9p is an evolutionarily conserved U3 snoRNP protein essential for earlypre-rRNA processing cleavages and requires box C for its association | Venema J, Vos HR, ..., Raue HA | 10.1017/s1355838200001369 |