Genome location: Pf3D7_12_v3:1,088,291..1,090,085(-)
Genome classification: Core
Product Description: parasitophorous vacuolar protein 2
SignalP Peptide: MFIIKCIVFVFIFCNGLLSVLG
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
| Function | GO:0044877 | protein-containing complex binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.13 | 0.94 |
| Trophozoite | expressed | 0.86 | 0.54 |
| Schizont | expressed | 0.32 | 0.80 |
| Gametocyte | expressed | 0.58 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1226900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.134 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1441700)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1441700)
Modification: Disrupted | RMgm-4537
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5E9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 24 | 10 | 42 |
| disruptive | 5 | 25 | 22 | 55 |
| missense | 5 | 25 | 20 | 46 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 49 | 16 | 40 |
| disruptive | 14 | 79 | 31 | 94 |
| missense | 9 | 60 | 30 | 67 |
PlasmoDB Total SNPs: 71
Non-coding: 47 | Synonymous: 18 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 495 | Molecular Weight (kDa): 57.333
UniProt ID(s): Q8I5E9
PDB ID(s): None
Isoelectric Point: 9.54
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28691708 | An exported protein-interacting complex involved in the trafficking of virulencedeterminants in Plasmodium-infected erythrocytes. | Batinovic S, McHugh E, ..., Tilley L | 10.1038/ncomms16044 |
| 28784333 | Identification of novel parasitophorous vacuole proteins in P. falciparumparasites using BioID. | Khosh-Naucke M, Becker J, ..., Spielmann T | 10.1016/j.ijmm.2017.07.007 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |