Product Description: potassium channel K1
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0016021 | integral component of membrane |
| Function | GO:0005267 | potassium channel activity |
| Function | GO:0005249 | voltage-gated potassium channel activity |
| Process | GO:0071805 | potassium ion transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.32 | 0.85 |
| Trophozoite | expressed | 0.77 | 0.59 |
| Schizont | possibly expressed | 0.49 | 0.70 |
| Gametocyte | possibly expressed | 0.50 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1227200
Resistome Missense Mutations: D1330Y
Resistome Compounds with Missense Mutations: MMV085203
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -2.944 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1442000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1442000)
Modification: Disrupted | RMgm-3952
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5E6
"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=0.03) with 7P9J (Global RMSD=17.47)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 81 | 59 | 139 |
| disruptive | 60 | 176 | 102 | 236 |
| missense | 40 | 141 | 83 | 185 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 190 | 85 | 152 |
| disruptive | 128 | 381 | 213 | 475 |
| missense | 71 | 280 | 176 | 302 |
PlasmoDB Total SNPs: 412
Non-coding: 243 | Synonymous: 107 | Nonsynonymous: 62 | Stop Codon: 0
Protein Length: 1966 | Molecular Weight (kDa): 232.187
UniProt ID(s): Q8I5E6
PDB ID(s): None
Isoelectric Point: 9.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013099 | Potassium channel domain |
| InterPro | IPR028325 | Voltage-gated potassium channel |
| PFam | PF07885 | Potassium channel domain |
| Superfamily | SSF81324 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18218136 | Characterization of two putative potassium channels in Plasmodium falciparum. | Waller KL, McBride SM, Kim K, McDonald TV | 10.1186/1475-2875-7-19 |
| 32957994 | Purification and initial characterization of Plasmodium falciparum K(+) channels,PfKch1 and PfKch2 produced in Saccharomyces cerevisiae. | Molbaek K, Tejada M, ..., Pedersen PA | 10.1186/s12934-020-01437-7 |