About Gene List

PF3D7_1227400

Genome location: Pf3D7_12_v3:1,108,744..1,112,924(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0031499 TRAMP complex
Component GO:0005730 nucleolus
Function GO:0004652 polynucleotide adenylyltransferase activity
Process GO:0071044 histone mRNA catabolic process
Process GO:0071050 sno(s)RNA polyadenylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.33 0.83
Trophozoite expressed 0.43 0.74
Schizont expressed 0.37 0.76
Gametocyte expressed 0.36 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1227400

Resistome Missense Mutations: E1139K

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.107 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5E4

"Best" AlphaFill ligand hit: 2TM (cmpcpp, Local RMSD=1.07) with 6YWN (Global RMSD=3.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_203722

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 46 30 53
disruptive 30 148 93 211
missense 20 113 68 162

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 103 42 85
disruptive 77 383 165 374
missense 45 272 123 223

PlasmoDB Total SNPs: 238

Non-coding: 101 | Synonymous: 79 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 1172 | Molecular Weight (kDa): 139.381

UniProt ID(s): Q8I5E4

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source Family ID Description
InterPro IPR043519 Nucleotidyltransferase superfamily
PFam N/A N/A
Superfamily SSF81301 Nucleotidyltransferase superfamily
Superfamily SSF81631

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104