About Gene List

PF3D7_1227500 (SOC2)

Genome location: Pf3D7_12_v3:1,113,526..1,122,666(-)

Genome classification: Core

Function and Localization

Product Description: protein SOC2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005875 microtubule associated complex
Component GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
Component GO:0005634 nucleus
Process GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
Process GO:0051726 regulation of cell cycle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.15 0.93
Trophozoite expressed 1.25 0.45
Schizont expressed 0.89 0.60
Gametocyte expressed 1.22 0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1227500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.997 | MFS: -2.712 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1442200)

Modification: Tagged | RMgm-4151

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5E3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532301

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 24 108 44 133
disruptive 109 289 157 367
missense 75 242 135 298

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 40 211 98 171
disruptive 204 671 306 650
missense 123 516 247 434

PlasmoDB Total SNPs: 526

Non-coding: 240 | Synonymous: 177 | Nonsynonymous: 109 | Stop Codon: 0

Protein Information

Protein Length: 2303 | Molecular Weight (kDa): 276.124

UniProt ID(s): Q8I5E3, Q8T358

PDB ID(s): None

Isoelectric Point: 9.82

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
28481199 Multiple short windows of calcium-dependent protein kinase 4 activity coordinatedistinct cell cycle events during Plasmodium gametogenesis Fang H, Klages N, ..., Brochet M 10.7554/eLife.26524
32568069 A divergent cyclin/cyclin-dependent kinase complex controls the atypicalreplication of a malaria parasite during gametogony and transmission Balestra AC, Zeeshan M, ..., Brochet M 10.7554/eLife.56474