Genome location: Pf3D7_12_v3:1,123,758..1,128,688(+)
Genome classification: Core
Product Description: kinetochore protein SPC24, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031262 | Ndc80 complex |
| Component | GO:0000776 | kinetochore |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.96 |
| Trophozoite | expressed | 0.55 | 0.69 |
| Schizont | expressed | 0.86 | 0.55 |
| Gametocyte | expressed | 0.92 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1227600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.246 | MFS: -2.617 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1444800)
Modification: Tagged | RMgm-5310
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5E2
"Best" AlphaFill ligand hit: PMP (pyridoxamine-5'-phosphate, Local RMSD=0.54) with 7KZ6 (Global RMSD=22.02)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 51 | 28 | 76 |
| disruptive | 39 | 135 | 90 | 186 |
| missense | 23 | 109 | 76 | 148 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 113 | 43 | 76 |
| disruptive | 73 | 308 | 149 | 379 |
| missense | 44 | 232 | 114 | 214 |
PlasmoDB Total SNPs: 363
Non-coding: 176 | Synonymous: 104 | Nonsynonymous: 83 | Stop Codon: 0
Protein Length: 1115 | Molecular Weight (kDa): 131.532
UniProt ID(s): Q8I5E2
PDB ID(s): None
Isoelectric Point: 8.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32501284 | Real-time dynamics of Plasmodium N DC80 reveals unusual modes of chromosomesegregation during parasite proliferation | Zeeshan M, Pandey R, ..., Tewari R | 10.1242/jcs.245753 |
| 36006241 | Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation | Brusini L, Dos Santos Pacheco N, ..., Brochet M | 10.1083/jcb.202111084 |
| 33591274 | Structural basis of Stu2 recruitment to yeast kinetochores | Zahm JA, Stewart MG, ..., Miller MP | 10.7554/eLife.65389 |
| 37950911 | A role for beta-1,6- and beta-1,3-glucans in kinetochore function in Saccharomycescerevisiae | Kshirsagar R, Munhoven A, Tran Nguyen TM, Ehrenhofer-Murray AE | 10.1093/genetics/iyad195 |
| 36810679 | Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochorestability in yeast | Tran Nguyen TM, Munhoven A, ..., Ehrenhofer-Murray AE | 10.1093/genetics/iyad028 |