PF3D7_1228000

Genome location: Pf3D7_12_v3:1,140,794..1,142,233(+)

Genome classification: Core

Function and Localization

Product Description: WPP motif-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1228000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.229 | MFS: -2.957 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5D8

"Best" AlphaFill ligand hit: PE0 (pterine, Local RMSD=4.72) with 6KCL (Global RMSD=16.52)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146148

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 64

Non-coding: 59 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 147 | Molecular Weight (kDa): 17.34

UniProt ID(s): Q8I5D8

PDB ID(s): None

Isoelectric Point: 10.52

Protein Domain Annotations: