PF3D7_1228100 (LRR13)

Genome location: Pf3D7_12_v3:1,141,583..1,143,194(-)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	possibly expressed	0.27	0.86
Schizont	possibly expressed	0.14	0.92
Gametocyte	possibly expressed	0.40	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1228100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.023 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1442800)

Relative Growth Rate: 1.03 ± 0.15
Confidence: 5.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1442800)

Modification: Disrupted | RMgm-3958

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5D7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104522

Most Similar Human Ortholog: E5RHF9

TM-align score: 0.88 | RMSD: 1.34

Seq Identity: 0.56 | Length: 88 / 447

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000129295	leucine rich repeat containing 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	14	14	35
disruptive	12	52	35	99
missense	7	35	24	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	33	33	42
disruptive	21	130	59	129
missense	10	79	51	90

PlasmoDB Total SNPs: 44

Non-coding: 31 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 447 | Molecular Weight (kDa): 52.886

UniProt ID(s): Q1L697, Q8I5D7

PDB ID(s): None

Isoelectric Point: 9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	PF14580	N/A
Superfamily	SSF52058	N/A