PF3D7_1228200

Genome location: Pf3D7_12_v3:1,143,645..1,146,406(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	expressed	0.16	0.91
Schizont	expressed	0.04	0.97
Gametocyte	not expressed	0.09	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1228200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.219 | MFS: -2.758 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1442900)

Relative Growth Rate: 0.07 ± 0.05
Confidence: 7.53

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5D6

"Best" AlphaFill ligand hit: SAL (2-hydroxybenzoic acid, Local RMSD=1.80) with 4EM2 (Global RMSD=18.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532916

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	37	15	47
disruptive	17	124	67	154
missense	12	78	55	127

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	72	31	51
disruptive	57	261	116	253
missense	20	180	91	145

PlasmoDB Total SNPs: 110

Non-coding: 44 | Synonymous: 42 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 818 | Molecular Weight (kDa): 98.444

UniProt ID(s): Q8I5D6

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A