About Gene List

PF3D7_1228400

Genome location: Pf3D7_12_v3:1,152,821..1,158,131(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.73 0.66
Trophozoite expressed 0.72 0.62
Schizont possibly expressed 0.35 0.79
Gametocyte expressed 0.48 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1228400

Resistome Missense Mutations: I1346K, I1348K, M1350K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.218 | MFS: -2.632 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1443100)

  • Relative Growth Rate: 0.12 ± 0.33
  • Confidence: 3.58

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5D4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533475

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 46 30 71
disruptive 69 173 87 201
missense 25 129 78 167

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 98 54 77
disruptive 122 344 141 315
missense 57 258 113 211

PlasmoDB Total SNPs: 480

Non-coding: 119 | Synonymous: 229 | Nonsynonymous: 116 | Stop Codon: 16

Protein Information

Protein Length: 1401 | Molecular Weight (kDa): 168.809

UniProt ID(s): Q8I5D4

PDB ID(s): None

Isoelectric Point: 8.37

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108