Genome location: Pf3D7_12_v3:1,160,654..1,163,264(-)
Genome classification: Core
Product Description: merozoite surface protein 9
SignalP Peptide: MMNMKIVLFSLLLFVIRWNIISC
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0003723 | RNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.32 | 0.86 |
| Trophozoite | expressed | 0.88 | 0.68 |
| Schizont | expressed | 3.94 | 0.12 |
| Gametocyte | expressed | 0.39 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1228600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.39 | MFS: -3.212 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_1445800)
Modification: Tagged | RMgm-1536
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A026
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 26 | 16 | 26 |
| disruptive | 56 | 102 | 40 | 102 |
| missense | 24 | 53 | 29 | 74 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 45 | 21 | 43 |
| disruptive | 85 | 153 | 68 | 124 |
| missense | 33 | 93 | 46 | 90 |
PlasmoDB Total SNPs: 118
Non-coding: 27 | Synonymous: 50 | Nonsynonymous: 41 | Stop Codon: 0
Protein Length: 743 | Molecular Weight (kDa): 86.623
UniProt ID(s): A0A144A026, C5HEE4, C5HEE5, C5HEE7, C5HEE9, C5HEF0, C5HEF3, C5HEF5, C5HEG0, C5HEG1, Q8I5D2, Q9NIH1
PDB ID(s): 2MU9
Isoelectric Point: 4.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 3309058 | Monoclonal antibody characterization of Plasmodium falciparum antigens in immunecomplexes formed when schizonts rupture in the presence of immune serum. | Chulay JD, Lyon JA, ..., Aikawa M | https://pubmed.ncbi.nlm.nih.gov/3309058/ |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18820076 | Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairsparasite invasion of erythrocytes. | Kadekoppala M, O'Donnell RA, ..., Holder AA | 10.1128/EC.00274-08 |
| 27503796 | Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. | Siau A, Huang X, ..., Preiser PR | 10.1038/srep31055 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 16289042 | Two Plasmodium falciparum merozoite proteins binding to erythrocyte band 3 form adirect complex | Kariuki MM, Li X, ..., Oh SS | https://pubmed.ncbi.nlm.nih.gov/16289042/ |
| 14630931 | A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyteinvasion receptor band 3 | Li X, Chen H, ..., Oh SS | 10.1074/jbc.M308716200 |
| 12797974 | Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the closerelationship of Plasmodium coatneyi to Plasmodium knowlesi | Vargas-Serrato E, Corredor V, Galinski MR | 10.1016/s1567-1348(03)00007-8 |
| 22649493 | Influence of HLA-DRB1 and HLA-DQB1 alleles on IgG antibody response to the P.vivax MSP-1, MSP-3alpha and MSP-9 in individuals from Brazilian endemic area | Lima-Junior JC, Rodrigues-da-Silva RN, ..., de Oliveira-Ferreira J | 10.1371/journal.pone.0036419 |
| 24044894 | The evolution and diversity of a low complexity vaccine candidate, merozoitesurface protein 9 (MSP-9), in Plasmodium vivax and closely related species | Chenet SM, Pacheco MA, ..., Escalante AA | 10.1016/j.meegid.2013.09.011 |
| 35141172 | Antigen Discovery in Circulating Extracellular Vesicles From Plasmodium vivaxPatients | Aparici-Herraiz I, Gualdron-Lopez M, ..., Del Portillo HA | 10.3389/fcimb.2021.811390 |
| 32751598 | Protective Immunity Induced by Virus-Like Particle Containing Merozoite SurfaceProtein 9 of Plasmodium berghei | Lee SH, Kang HJ, ..., Quan FS | 10.3390/vaccines8030428 |
| 32711079 | Structural diversity, natural selection and intragenic recombination in thePlasmodium vivax merozoite surface protein 9 locus in Thailand | Songsaigath S, Putaporntip C, Kuamsab N, Jongwutiwes S | 10.1016/j.meegid.2020.104467 |
| 19463923 | Sequence diversity and evolutionary dynamics of the dimorphic antigen merozoitesurface protein-6 and other Msp genes of Plasmodium falciparum | Roy SW, Weedall GD, ..., Ferreira MU | 10.1016/j.gene.2009.05.007 |
| 18272263 | Plasmodium berghei merozoite surface protein-9: immunogenicity and protectiveefficacy using a homologous challenge model | Lopera-Mesa TM, Kushwaha A, Mohmmed A, Chauhan VS | 10.1016/j.vaccine.2007.12.042 |
| 33547377 | Immunoglobulin G responses to variant forms of Plasmodium vivax merozoite surfaceprotein 9 upon natural infection in Thailand | Songsaigath S, Makiuchi T, ..., Jongwutiwes S | 10.1038/s41598-021-82928-4 |
| 25157665 | Human erythrocyte band 3 functions as a receptor for the sialic acid-independentinvasion of Plasmodium falciparum. Role of the RhopH3-MSP1 complex | Baldwin M, Yamodo I, ..., Chishti AH | 10.1016/j.bbamcr.2014.08.008 |
| 35214662 | Protection and Alleviated Inflammation Induced by Virus-like Particle VaccinesContaining Plasmodium berghei MSP-8, MSP-9 and RAP1 | Lee SH, Chu KB, Kang HJ, Quan FS | 10.3390/vaccines10020203 |
| 24373342 | Natural antibody response to Plasmodium falciparum merozoite antigens MSP5, MSP9and EBA175 is associated to clinical protection in the Brazilian Amazon | Medeiros MM, Fotoran WL, ..., Wunderlich G | 10.1186/1471-2334-13-608 |
| 15121316 | Immunogenicity of Plasmodium vivax merozoite surface protein-9 recombinantproteins expressed in E. coli | Oliveira-Ferreira J, Vargas-Serrato E, ..., Galinski MR | 10.1016/j.vaccine.2003.07.021 |