PF3D7_1228700

Genome location: Pf3D7_12_v3:1,164,781..1,169,629(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MYNIVYIFLYLIVIFCLQWESVVS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	expressed	0.78	0.59
Schizont	expressed	0.77	0.62
Gametocyte	expressed	0.99	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1228700

Resistome Missense Mutations: S652P

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.702 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1443400)

Relative Growth Rate: 0.07 ± 0.05
Confidence: 7.36

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5D1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_159024

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	46	35	64
disruptive	20	87	52	143
missense	20	75	45	112

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	93	58	76
disruptive	62	189	119	247
missense	37	147	101	180

PlasmoDB Total SNPs: 152

Non-coding: 87 | Synonymous: 43 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 1135 | Molecular Weight (kDa): 136.557

UniProt ID(s): Q8I5D1

PDB ID(s): None

Isoelectric Point: 7.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895