PF3D7_1228800

Genome location: Pf3D7_12_v3:1,169,145..1,179,868(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0033186	CAF-1 complex
Component	GO:0005634	nucleus
Process	GO:0006334	nucleosome assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.56	0.75
Trophozoite	expressed	1.97	0.22
Schizont	expressed	2.07	0.25
Gametocyte	expressed	2.15	0.16

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1228800

Resistome Missense Mutations: Y800D, D806Y, A832V, D1406E, R1411Q, E1414D

Resistome Compounds with Missense Mutations: AN13762, MMV665794, NEU-1029, OSM-S-106

Resistome # Samples with Disruptive Mutations: 9 (8 missense, 8 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.425 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158520

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	41	143	80	191
disruptive	195	471	247	584
missense	90	340	184	433

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	68	264	123	213
disruptive	324	982	415	844
missense	152	667	320	548

PlasmoDB Total SNPs: 727

Non-coding: 162 | Synonymous: 289 | Nonsynonymous: 276 | Stop Codon: 0

Protein Information

Protein Length: 3209 | Molecular Weight (kDa): 378.91

UniProt ID(s): A0A516MWQ2, Q8I5D0

PDB ID(s): None

Isoelectric Point: 9.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104