About Gene List

PF3D7_1228900

Genome location: Pf3D7_12_v3:1,180,404..1,185,971(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.28 0.86
Trophozoite expressed 0.68 0.64
Schizont expressed 0.09 0.95
Gametocyte expressed 0.94 0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1228900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -3.065 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1443700)

  • Relative Growth Rate: 0.10 ± nan
  • Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5C9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146151

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 33 21 47
disruptive 17 49 22 81
missense 15 47 21 69

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 65 37 52
disruptive 29 119 48 155
missense 21 90 42 108

PlasmoDB Total SNPs: 467

Non-coding: 376 | Synonymous: 78 | Nonsynonymous: 12 | Stop Codon: 1

Protein Information

Protein Length: 760 | Molecular Weight (kDa): 91.342

UniProt ID(s): Q8I5C9

PDB ID(s): None

Isoelectric Point: 9.65

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104