PF3D7_1229000

Genome location: Pf3D7_12_v3:1,186,132..1,192,040(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1229000

Resistome Missense Mutations: N362I

Resistome Compounds with Missense Mutations: Atovaquone

Resistome # Samples with Disruptive Mutations: 8 (8 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.063 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1443600)

• Relative Growth Rate: 0.01 ± 0.60
• Confidence: 2.41

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5C8

"Best" AlphaFill ligand hit: T3F (thymidine-5'-diphosphate-alpha-d-3,6-dideoxy-3-aminogalactose, Local RMSD=1.52) with 7N7B (Global RMSD=20.71)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532687

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 251

Non-coding: 42 | Synonymous: 134 | Nonsynonymous: 75 | Stop Codon: 0

Protein Information

Protein Length: 1834 | Molecular Weight (kDa): 223.746

UniProt ID(s): Q8I5C8

PDB ID(s): None

Isoelectric Point: 7.32

Protein Domain Annotations: