Genome location: Pf3D7_12_v3:1,204,991..1,208,108(+)
Genome classification: Core
Product Description: PhIL1-interacting candidate PIC1
SignalP Peptide: MKLKYHLFFLIIFIQDILC
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 1.00 | 0.60 |
| Trophozoite | not expressed | 0.74 | 0.63 |
| Schizont | expressed | 1.57 | 0.36 |
| Gametocyte | not expressed | 1.02 | 0.48 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1229300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.818 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5C6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 32 | 22 | 48 |
| disruptive | 87 | 167 | 96 | 203 |
| missense | 41 | 112 | 60 | 154 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 72 | 38 | 61 |
| disruptive | 146 | 385 | 154 | 330 |
| missense | 62 | 260 | 114 | 172 |
PlasmoDB Total SNPs: 149
Non-coding: 3 | Synonymous: 63 | Nonsynonymous: 83 | Stop Codon: 0
Protein Length: 990 | Molecular Weight (kDa): 117.482
UniProt ID(s): Q8I5C6
PDB ID(s): None
Isoelectric Point: 5.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 33830607 | Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. | Wichers JS, Wunderlich J, ..., Gilberger TW | 10.1111/cmi.13341 |
| 32310973 | Incompatible erythrocyte transfusion with lipopolysaccharide induces acute lunginjury in a novel rat model | Gregory Rivera M, Sampson AC, ..., Krishna NK | 10.1371/journal.pone.0230482 |