About Gene List

PF3D7_1229600

Genome location: Pf3D7_12_v3:1,213,472..1,217,959(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.17 0.92
Trophozoite expressed 1.13 0.45
Schizont expressed 0.83 0.56
Gametocyte expressed 1.16 0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1229600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.462 | MFS: -2.449 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5C3

"Best" AlphaFill ligand hit: NMY (mycifradin, Local RMSD=0.13) with 5IQE (Global RMSD=18.72)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533433

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 30 14 43
disruptive 104 128 72 123
missense 42 77 47 79

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 62 28 60
disruptive 147 231 88 237
missense 55 141 59 137

PlasmoDB Total SNPs: 332

Non-coding: 68 | Synonymous: 149 | Nonsynonymous: 115 | Stop Codon: 0

Protein Information

Protein Length: 1163 | Molecular Weight (kDa): 138.723

UniProt ID(s): Q8I5C3

PDB ID(s): None

Isoelectric Point: 5.88

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895