About Gene List

PF3D7_1229700

Genome location: Pf3D7_12_v3:1,217,961..1,219,134(+)

Genome classification: Core

Function and Localization

Product Description: mitochondrial respiratory chain complex II subunit, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Component GO:0045273 respiratory chain complex II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.03 0.98
Trophozoite no data 0.28 0.82
Schizont no data 0.14 0.91
Gametocyte no data 0.38 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1229700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.776 | MFS: -3.051 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3K8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149556

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 78

Non-coding: 78 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 82 | Molecular Weight (kDa): 9.924

UniProt ID(s): C6S3K8

PDB ID(s): None

Isoelectric Point: 10.73

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
33651838 Complexome profile of Toxoplasma gondii mitochondria identifies divergentsubunits of respiratory chain complexes including new subunits of cytochrome bc1complex. Maclean AE, Bridges HR, ..., Sheiner L 10.1371/journal.ppat.1009301
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21