PF3D7_1229900

Genome location: Pf3D7_12_v3:1,227,925..1,233,204(-)

Genome classification: Core

Function and Localization

Product Description: dynein regulatory complex subunit 7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031514	motile cilium
Process	GO:0048870	cell motility

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1229900.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.234 | #Insertions: 8

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1444600)

Relative Growth Rate: 0.64 ± 0.33
Confidence: 3.61

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1444600)

Modification: Disrupted | RMgm-3969

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1R4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103795

Most Similar Human Ortholog: H3BQY5

TM-align score: 0.74 | RMSD: 1.97

Seq Identity: 0.12 | Length: 51 / 690

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000159625	dynein regulatory complex subunit 7
ENSG00000182885	adhesion G protein-coupled receptor G3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	21	6	31
disruptive	3	36	28	63
missense	3	36	28	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	43	16	38
disruptive	16	94	52	117
missense	12	74	38	94

PlasmoDB Total SNPs: 418

Non-coding: 386 | Synonymous: 22 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 690 | Molecular Weight (kDa): 84.072

UniProt ID(s): A0A144A2M6

PDB ID(s): None

Isoelectric Point: 8.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR033551	Dynein regulatory complex subunit 7
PFam	N/A	N/A
Superfamily	N/A	N/A