PF3D7_1230000

Genome location: Pf3D7_12_v3:1,233,352..1,241,605(+)

Genome classification: Core

Function and Localization

Product Description: TBC domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.36	0.83
Trophozoite	expressed	1.01	0.48
Schizont	expressed	0.43	0.76
Gametocyte	expressed	1.22	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1230000

Resistome Missense Mutations: D828Y

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 4 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.033 | #Insertions: 10

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1444700)

Relative Growth Rate: 0.10 ± nan
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A0A3

"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=10.13) with 4O6Z (Global RMSD=16.96)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533759

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	75	44	105
disruptive	107	243	110	303
missense	53	160	89	219

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	155	70	138
disruptive	200	487	216	458
missense	89	334	175	284

PlasmoDB Total SNPs: 555

Non-coding: 252 | Synonymous: 163 | Nonsynonymous: 138 | Stop Codon: 2

Protein Information

Protein Length: 2001 | Molecular Weight (kDa): 241.141

UniProt ID(s): A0A144A0A3

PDB ID(s): None

Isoelectric Point: 9.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000195	Rab-GTPase-TBC domain
InterPro	IPR035969	Rab-GTPase-TBC domain superfamily
InterPro	IPR036873	Rhodanese-like domain superfamily
PFam	PF00566	Rab-GTPase-TBC domain
Superfamily	SSF47923	Rab-GTPase-TBC domain superfamily
Superfamily	SSF52821	Rhodanese-like domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094