Genome location: Pf3D7_12_v3:1,241,879..1,243,601(-)
Genome classification: Core
Product Description: thioredoxin-like associated protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0055028 | cortical microtubule |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.15 | 0.90 |
| Gametocyte | expressed | 0.97 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1230100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.728 | MFS: -2.293 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1444800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1444800)
Modification: Disrupted | RMgm-3970
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5B9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 19 | 11 | 25 |
| disruptive | 18 | 41 | 31 | 70 |
| missense | 16 | 36 | 26 | 57 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 43 | 15 | 31 |
| disruptive | 23 | 111 | 46 | 114 |
| missense | 20 | 88 | 42 | 76 |
PlasmoDB Total SNPs: 35
Non-coding: 7 | Synonymous: 12 | Nonsynonymous: 16 | Stop Codon: 0
Protein Length: 524 | Molecular Weight (kDa): 61.509
UniProt ID(s): Q8I5B9
PDB ID(s): None
Isoelectric Point: 7.94
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23873863 | Novel thioredoxin-like proteins are components of a protein complex coating thecortical microtubules of Toxoplasma gondii. | Liu J, Wetzel L, ..., Hu K | 10.1128/EC.00082-13 |