Genome location: Pf3D7_12_v3:1,249,652..1,250,988(-)
Genome classification: Core
Product Description: subpellicular microtubule protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020025 | subpellicular microtubule |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | expressed | 0.15 | 0.90 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1230300
Resistome Missense Mutations: L3H
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.467 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5B7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 8 | 3 | 15 |
| disruptive | 1 | 13 | 8 | 29 |
| missense | 1 | 13 | 8 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 21 | 8 | 16 |
| disruptive | 3 | 35 | 24 | 46 |
| missense | 3 | 33 | 22 | 36 |
PlasmoDB Total SNPs: 54
Non-coding: 42 | Synonymous: 8 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 258 | Molecular Weight (kDa): 30.19
UniProt ID(s): Q8I5B7
PDB ID(s): None
Isoelectric Point: 9.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22021240 | SPM1 stabilizes subpellicular microtubules in Toxoplasma gondii. | Tran JQ, Li C, ..., Morrissette NS | 10.1128/EC.05161-11 |