PF3D7_1231300

Genome location: Pf3D7_12_v3:1,286,273..1,289,606(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005929	cilium

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.58	0.75
Gametocyte	not expressed	0.49	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1231300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.516 | #Insertions: 12

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1446000)

Relative Growth Rate: 0.90 ± 0.18
Confidence: 4.79

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1446000)

Modification: Disrupted | RMgm-3979

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5A7

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=5.10) with 5OXF (Global RMSD=25.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103131

Most Similar Human Ortholog: A0A6Q8PGQ7

TM-align score: 0.71 | RMSD: 1.92

Seq Identity: 0.32 | Length: 146 / 952

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000116198	centrosomal protein 104

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	44	19	45
disruptive	12	83	47	121
missense	12	78	43	107

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	74	22	50
disruptive	36	164	91	161
missense	21	143	72	120

PlasmoDB Total SNPs: 80

Non-coding: 24 | Synonymous: 34 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 952 | Molecular Weight (kDa): 112.851

UniProt ID(s): Q8I5A7

PDB ID(s): None

Isoelectric Point: 6.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008979	Galactose-binding-like domain superfamily
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold
Superfamily	SSF49785	Galactose-binding-like domain superfamily