About Gene List

PF3D7_1231400 (ICM1)

Genome location: Pf3D7_12_v3:1,290,102..1,297,082(-)

Genome classification: Core

Function and Localization

Product Description: membrane protein ICM1

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0005515 protein binding
Process GO:0044409 entry into host
Process GO:0035891 exit from host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.41 0.84
Trophozoite not expressed 0.29 0.83
Schizont not expressed 0.62 0.76
Gametocyte not expressed 0.79 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1231400

Resistome Missense Mutations: P259T

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.152 | MFS: -2.784 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1446100)

  • Relative Growth Rate: 0.18 ± 0.16
  • Confidence: 5.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_1446100)

Modification: Disrupted | RMgm-4331

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5A6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109770

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 68 37 83
disruptive 37 188 111 277
missense 25 165 105 245

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 130 49 103
disruptive 84 414 172 408
missense 44 333 148 314

PlasmoDB Total SNPs: 187

Non-coding: 34 | Synonymous: 104 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 1944 | Molecular Weight (kDa): 228.961

UniProt ID(s): Q8I5A6

PDB ID(s): None

Isoelectric Point: 8.07

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
33762339 Ca(2+) signals critical for egress and gametogenesis in malaria parasites dependon a multipass membrane protein that interacts with P KG Balestra AC, Koussis K, ..., Brochet M 10.1126/sciadv.abe5396