PF3D7_1231500

Genome location: Pf3D7_12_v3:1,298,137..1,300,451(+)

Genome classification: Core

Function and Localization

Product Description: mitosis protein dim1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.1.1.183 (18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0046540	U4/U6 x U5 tri-snRNP complex
Component	GO:0005682	U5 snRNP
Component	GO:0005681	spliceosomal complex
Process	GO:0000375	RNA splicing, via transesterification reactions
Process	GO:0000245	spliceosomal complex assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.03	0.98
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1231500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.449 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5A5

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.1.1.183	18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase	No BRENDA inhibitors

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102797

Most Similar Human Ortholog: P83876

TM-align score: 0.97 | RMSD: 1.23

Seq Identity: 0.77 | Length: 139 / 139

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000141759	thioredoxin like 4A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 179

Non-coding: 176 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 139 | Molecular Weight (kDa): 16.539

UniProt ID(s): Q8I5A5

PDB ID(s): None

Isoelectric Point: 4.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004123	Dim1 family
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	PF02966	Dim1 family
Superfamily	SSF52833	Thioredoxin-like superfamily