About Gene List

PF3D7_1231800

Genome location: Pf3D7_12_v3:1,312,553..1,320,504(+)

Genome classification: Core

Function and Localization

Product Description: asparagine-rich protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.84 0.62
Trophozoite possibly expressed 1.19 0.43
Schizont possibly expressed 0.50 0.73
Gametocyte not expressed 0.43 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1231800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.598 | #Insertions: 20

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5A3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104538

Most Similar Human Ortholog: D6RCL2

TM-align score: 0.32 | RMSD: 4.85

Seq Identity: 0.05 | Length: 58 / 1824

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000131711 microtubule associated protein 1B
ENSG00000166963 microtubule associated protein 1A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 21 85 30 98
disruptive 120 261 135 377
missense 56 184 107 295

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 39 165 61 113
disruptive 188 578 274 545
missense 95 404 201 327

PlasmoDB Total SNPs: 535

Non-coding: 178 | Synonymous: 193 | Nonsynonymous: 164 | Stop Codon: 0

Protein Information

Protein Length: 1824 | Molecular Weight (kDa): 212.658

UniProt ID(s): Q25771, Q8I5A3

PDB ID(s): None

Isoelectric Point: 6.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0