Product Description: cytochrome b5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020020 | food vacuole |
| Component | GO:0043231 | intracellular membrane-bounded organelle |
| Component | GO:0016020 | membrane |
| Function | GO:0009055 | electron transfer activity |
| Function | GO:0020037 | heme binding |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.29 | 0.82 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | expressed | 0.74 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1232300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.208 | MFS: -3.279 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I599
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100589
Most Similar Human Ortholog: P00167
TM-align score: 0.58 | RMSD: 3.01
Seq Identity: 0.26 | Length: 92 / 157
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103018 | cytochrome b5 type B |
| ENSG00000166347 | cytochrome b5 type A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 9 | 5 | 8 |
| disruptive | 4 | 15 | 5 | 22 |
| missense | 2 | 14 | 4 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 14 | 6 | 18 |
| disruptive | 11 | 29 | 21 | 53 |
| missense | 6 | 20 | 14 | 34 |
PlasmoDB Total SNPs: 183
Non-coding: 172 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 157 | Molecular Weight (kDa): 18.244
UniProt ID(s): Q8I599
PDB ID(s): None
Isoelectric Point: 8.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001199 | Cytochrome b5-like heme/steroid binding domain |
| InterPro | IPR036400 | Cytochrome b5-like heme/steroid binding domain superfamily |
| PFam | PF00173 | Cytochrome b5-like heme/steroid binding domain |
| Superfamily | SSF55856 | Cytochrome b5-like heme/steroid binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20493843 | Plasmodium falciparum: nitric oxide modulates heme speciation in isolated foodvacuoles. | Ostera G, Tokumasu F, ..., Rodgers KR | 10.1016/j.exppara.2010.05.006 |