PF3D7_1232500

Genome location: Pf3D7_12_v3:1,339,320..1,343,378(-)

Genome classification: Core

Function and Localization

Product Description: CG2-related protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.48	0.82
Trophozoite	expressed	0.52	0.74
Schizont	expressed	2.45	0.11
Gametocyte	expressed	0.85	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1232500

Resistome Missense Mutations: I713K, N715Y, D721N, D722N, N728D

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 6 (6 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.591 | #Insertions: 8

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1447200)

Relative Growth Rate: 0.78 ± 0.23
Confidence: 4.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1447200)

Modification: Disrupted | RMgm-3985

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1B9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532380

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	37	40	63
disruptive	46	102	57	133
missense	26	70	43	116

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	88	48	66
disruptive	76	204	93	208
missense	35	150	71	155

PlasmoDB Total SNPs: 219

Non-coding: 105 | Synonymous: 64 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1071 | Molecular Weight (kDa): 127.12

UniProt ID(s): A0A144A1B9

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011004	Trimeric LpxA-like superfamily
PFam	N/A	N/A
Superfamily	SSF51161	Trimeric LpxA-like superfamily
Superfamily	SSF52047

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104