About Gene List

PF3D7_1232600

Genome location: Pf3D7_12_v3:1,344,039..1,345,894(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.11 0.95
Trophozoite possibly expressed 0.24 0.85
Schizont expressed 0.48 0.75
Gametocyte expressed 0.50 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1232600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -2.998 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I596

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=2.39) with 7S01 (Global RMSD=21.73)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532995

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 11 14 15
disruptive 10 34 22 64
missense 7 25 20 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 24 12 21
disruptive 13 95 51 87
missense 8 68 38 61

PlasmoDB Total SNPs: 93

Non-coding: 64 | Synonymous: 14 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 362 | Molecular Weight (kDa): 43.746

UniProt ID(s): Q8I596

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21