Genome location: Pf3D7_12_v3:1,345,905..1,351,253(+)
Genome classification: Core
Product Description: Nd9 protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Process | GO:0044409 | entry into host |
| Process | GO:0006887 | exocytosis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.10 | 0.94 |
| Schizont | possibly expressed | 0.31 | 0.79 |
| Gametocyte | possibly expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1232700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.852 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1447400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A4C1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 36 | 27 | 42 |
| disruptive | 12 | 32 | 26 | 90 |
| missense | 12 | 32 | 24 | 71 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 64 | 37 | 50 |
| disruptive | 23 | 91 | 67 | 160 |
| missense | 19 | 72 | 51 | 116 |
PlasmoDB Total SNPs: 426
Non-coding: 386 | Synonymous: 33 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 833 | Molecular Weight (kDa): 100.051
UniProt ID(s): A0A144A4C1
PDB ID(s): None
Isoelectric Point: 8.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 33495622 | An Alveolata secretory machinery adapted to parasite host cell invasion. | Aquilini E, Cova MM, ..., Lebrun M | 10.1038/s41564-020-00854-z |
| 26715306 | Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected humanpathogen | Lin RH, Lai DH, ..., Lun ZR | 10.1186/s13071-015-1281-8 |
| 34404783 | In situ ultrastructures of two evolutionarily distant apicomplexan rhoptrysecretion systems | Mageswaran SK, Guerin A, ..., Chang YW | 10.1038/s41467-021-25309-9 |