Product Description: conserved protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005730 | nucleolus |
Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.20 | 0.90 |
Trophozoite | expressed | 0.31 | 0.80 |
Schizont | expressed | 0.14 | 0.90 |
Gametocyte | expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1233100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.373 | MFS: -3.77 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1447800)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1447800)
Modification: Tagged | RMgm-955
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I591
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101764
Most Similar Human Ortholog: Q9Y421
TM-align score: 0.33 | RMSD: 3.74
Seq Identity: 0.21 | Length: 56 / 135
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000105058 | family with sequence similarity 32 member A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 104
Non-coding: 93 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 1
Protein Length: 135 | Molecular Weight (kDa): 15.918
UniProt ID(s): Q8I591
PDB ID(s): None
Isoelectric Point: 10.11
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR013865 | Protein FAM32A |
PFam | PF08555 | Protein FAM32A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |