About Gene List

PF3D7_1233100

Genome location: Pf3D7_12_v3:1,359,169..1,360,369(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005730 nucleolus
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.20 0.90
Trophozoite expressed 0.31 0.80
Schizont expressed 0.14 0.90
Gametocyte expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1233100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.373 | MFS: -3.77 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1447800)

  • Relative Growth Rate: 0.08 ± 0.10
  • Confidence: 6.04

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1447800)

Modification: Tagged | RMgm-955

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I591

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101764

Most Similar Human Ortholog: Q9Y421

TM-align score: 0.33 | RMSD: 3.74

Seq Identity: 0.21 | Length: 56 / 135

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000105058 family with sequence similarity 32 member A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 104

Non-coding: 93 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 135 | Molecular Weight (kDa): 15.918

UniProt ID(s): Q8I591

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013865 Protein FAM32A
PFam PF08555 Protein FAM32A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108