PF3D7_1233400

Genome location: Pf3D7_12_v3:1,379,747..1,383,501(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.32	0.84
Trophozoite	expressed	0.30	0.82
Schizont	expressed	0.06	0.96
Gametocyte	expressed	0.58	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1233400

Resistome Missense Mutations: E19K

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.975 | MFS: -2.538 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1C7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533043

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	29	17	31
disruptive	25	75	48	105
missense	16	64	41	89

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	58	19	46
disruptive	44	188	65	180
missense	28	145	49	111

PlasmoDB Total SNPs: 275

Non-coding: 217 | Synonymous: 33 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 616 | Molecular Weight (kDa): 74.251

UniProt ID(s): A0A144A1C7

PDB ID(s): None

Isoelectric Point: 9.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A