About Gene List

PF3D7_1233600 (AARP1)

Genome location: Pf3D7_12_v3:1,383,267..1,402,631(+)

Genome classification: Core

Function and Localization

Product Description: asparagine and aspartate rich protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005886 plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.45 0.43
Trophozoite expressed 2.41 0.14
Schizont expressed 0.95 0.58
Gametocyte expressed 2.59 0.10

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1233600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.984 | MFS: -2.832 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1448200)

Modification: Disrupted | RMgm-3992

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533320

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 42 231 134 285
disruptive 249 522 299 756
missense 148 373 242 617

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 82 440 171 303
disruptive 410 1018 508 1080
missense 216 728 402 804

PlasmoDB Total SNPs: 848

Non-coding: 198 | Synonymous: 347 | Nonsynonymous: 301 | Stop Codon: 2

Protein Information

Protein Length: 5439 | Molecular Weight (kDa): 646.337

UniProt ID(s): Q8I586, Q94648

PDB ID(s): None

Isoelectric Point: 6.38

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003126 Zinc finger, UBR-type
InterPro IPR044046 E3 ubiquitin-protein ligase UBR-like, C-terminal
PFam PF02207 Zinc finger, UBR-type
PFam PF18995 E3 ubiquitin-protein ligase UBR-like, C-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9234746 Plasmodium falciparum AARP1, a giant protein containing repeated motifs rich inasparagine and aspartate residues, is associated with the infected erythrocytemembrane. Barale JC, Candelle D, ..., Langsley G 10.1128/iai.65.8.3003-3010.1997
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104