About Gene List

PF3D7_1233800

Genome location: Pf3D7_12_v3:1,405,062..1,406,293(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite expressed 0.57 0.67
Schizont expressed 0.33 0.79
Gametocyte expressed 0.41 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1233800

Resistome Missense Mutations: R70K

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.151 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I584

"Best" AlphaFill ligand hit: SFG (sinefungin, Local RMSD=13.45) with 7RFK (Global RMSD=20.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149557

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 13 4 19
disruptive 2 6 9 26
missense 2 6 9 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 24 4 16
disruptive 2 33 19 51
missense 2 28 16 30

PlasmoDB Total SNPs: 134

Non-coding: 127 | Synonymous: 3 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 206 | Molecular Weight (kDa): 24.405

UniProt ID(s): Q8I584

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21