About Gene List

PF3D7_1234000

Genome location: Pf3D7_12_v3:1,411,288..1,413,290(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite possibly expressed 0.32 0.80
Schizont possibly expressed 0.11 0.92
Gametocyte expressed 0.60 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1234000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.015 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I582

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149558

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 17 8 28
disruptive 4 20 17 47
missense 4 20 16 43

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 30 18 32
disruptive 5 67 55 101
missense 4 53 43 75

PlasmoDB Total SNPs: 107

Non-coding: 82 | Synonymous: 22 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 421 | Molecular Weight (kDa): 50.656

UniProt ID(s): Q8I582

PDB ID(s): None

Isoelectric Point: 9.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21