Genome location: Pf3D7_12_v3:1,414,349..1,426,825(+)
Genome classification: Core
Product Description: bromodomain protein 5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0005667 | transcription regulator complex |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.31 | 0.46 |
| Trophozoite | expressed | 1.80 | 0.23 |
| Schizont | expressed | 1.21 | 0.42 |
| Gametocyte | expressed | 1.54 | 0.30 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1234100
Resistome Missense Mutations: D133Y
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 2 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.918 | MFS: -2.923 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 61 | 142 | 74 | 202 |
| disruptive | 244 | 598 | 276 | 671 |
| missense | 118 | 413 | 208 | 493 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 81 | 285 | 160 | 214 |
| disruptive | 465 | 1140 | 535 | 1048 |
| missense | 206 | 788 | 357 | 656 |
PlasmoDB Total SNPs: 655
Non-coding: 40 | Synonymous: 345 | Nonsynonymous: 270 | Stop Codon: 0
Protein Length: 3896 | Molecular Weight (kDa): 466.016
UniProt ID(s): Q8I581
PDB ID(s): None
Isoelectric Point: 8.54
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001487 | Bromodomain |
| InterPro | IPR036427 | Bromodomain-like superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF47370 | Bromodomain-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |
| 27083360 | Different action patterns of glucoamylases on branched gluco-oligosaccharidesfrom amylopectin | Jonathan MC, van Brussel M, Scheffers MS, Kabel MA | 10.1016/j.carbpol.2016.02.005 |