Genome location: Pf3D7_12_v3:1,436,790..1,439,349(-)
Genome classification: Core
Product Description: microgamete surface protein MiGS, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0044310 | osmiophilic body |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.01 | 0.99 |
| Schizont | not expressed | 0.01 | 1.00 |
| Gametocyte | not expressed | 0.31 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1234400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.176 | MFS: -2.691 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1449000)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1451500)
Modification: Disrupted | RMgm-4410
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I578
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 24 | 26 | 33 |
| disruptive | 13 | 47 | 42 | 82 |
| missense | 8 | 46 | 41 | 76 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 69 | 26 | 40 |
| disruptive | 30 | 120 | 61 | 121 |
| missense | 17 | 106 | 54 | 91 |
PlasmoDB Total SNPs: 151
Non-coding: 85 | Synonymous: 40 | Nonsynonymous: 26 | Stop Codon: 0
Protein Length: 656 | Molecular Weight (kDa): 77.093
UniProt ID(s): Q8I578
PDB ID(s): None
Isoelectric Point: 7.77
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR021109 | Aspartic peptidase domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF50630 | Aspartic peptidase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 29316140 | A male gametocyte osmiophilic body and microgamete surface protein of the rodentmalaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in maleosmiophilic body formation and exflagellation. | Tachibana M, Ishino T, ..., Torii M | 10.1111/cmi.12821 |