PF3D7_1234500

Genome location: Pf3D7_12_v3:1,439,751..1,441,606(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.45	0.78
Trophozoite	expressed	0.44	0.74
Schizont	possibly expressed	0.10	0.93
Gametocyte	possibly expressed	0.54	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1234500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -2.891 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I577

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532704

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	14	15	20
disruptive	9	41	17	44
missense	7	39	15	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	26	25	25
disruptive	21	62	39	67
missense	15	54	32	57

PlasmoDB Total SNPs: 74

Non-coding: 59 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 384 | Molecular Weight (kDa): 46.677

UniProt ID(s): Q8I577

PDB ID(s): None

Isoelectric Point: 8.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A